FANCF
FANCF is a protein that plays a crucial role in DNA repair and genome stability. It is a component of the FA (Fanconi anemia) core complex, which is involved in the recognition and repair of DNA interstrand crosslinks (ICLs). FANCF is encoded by the FANCF gene, which is located on chromosome 16q24.3. Mutations in the FANCF gene are associated with Fanconi anemia, a rare genetic disorder characterized by bone marrow failure, developmental abnormalities, and an increased risk of cancer.
The FANCF protein contains several functional domains, including a FANC domain, a C-terminal domain, and a coiled-coil
FANCF is expressed in various tissues, including bone marrow, liver, and kidney. Its expression is regulated
In summary, FANCF is a protein that plays a critical role in DNA repair and genome stability.