Exportin4

Exportin4 is a protein that in humans is encoded by the XPO4 gene. The protein encoded by this gene is a member of the importin-beta family of nuclear transport receptors. These receptors are involved in the active transport of macromolecules between the nucleus and the cytoplasm. Specifically, Exportin4 mediates the export of certain proteins from the nucleus to the cytoplasm. It functions as a nuclear exporter, facilitating the movement of cargo molecules through nuclear pore complexes. The gene XPO4 is located on chromosome 17. Exportin4 plays a role in various cellular processes by regulating the localization of its cargo proteins. Research has implicated Exportin4 in processes such as cell signaling, gene expression regulation, and the maintenance of genomic stability. Dysregulation of Exportin4 has been linked to certain diseases, although further research is ongoing to fully understand these connections. Its interaction with specific cargo proteins is crucial for its function, and identifying these cargo molecules is an active area of investigation in molecular biology and cell biology.