EphA5

EphA5 is a member of the Eph receptor tyrosine kinase family. These receptors are involved in cell-to-cell communication and play critical roles in embryonic development, tissue repair, and neuronal signaling. EphA5 specifically mediates cell adhesion and repulsion through interactions with its Ephrin ligands. The EphA5 gene is located on chromosome 1 in humans. Expression of EphA5 is observed in various tissues, including the developing and adult nervous system, as well as in some epithelial tissues. Its function in the nervous system is particularly important for processes like axon guidance and synapse formation. Dysregulation or mutations in EphA5 have been implicated in certain neurological disorders and potentially in cancer progression. The interaction between EphA5 and its ligands leads to intracellular signaling cascades that can influence cell migration, differentiation, and survival. Research into EphA5 continues to uncover its diverse roles in both normal physiological processes and pathological conditions.