Eotaxine

Eotaxine is a fictional chemical compound used in speculative pharmacology and science fiction to explore concepts in immunomodulation and drug design. The name echoes eotaxin, a real family of chemokines involved in eosinophil recruitment.

In the fictional account, Eotaxine is a small organic molecule featuring a heterocyclic core with polar substituents, giving moderate aqueous solubility and lipophilicity suitable for cell-based assays. Reported approximate molecular weight is in the 300–400 dalton range.

Proposed mechanism: Eotaxine is described as a selective antagonist of a hypothetical eosinophil-attractant receptor, designated ETR-1, thereby blocking signaling that mediates eosinophil chemotaxis. In vitro models show reduced eosinophil migration toward simulated chemokine gradients; in animal models, decreased tissue eosinophilia is noted.

Applications and status: Used primarily as a teaching tool and in thought experiments about receptor pharmacology and target validation. There are no clinical studies, regulatory status, or evidence of real-world production; it is not approved for any indication.

Synthesis and structure-activity notes: The fictional literature outlines a three-step synthesis from commercially available starting materials, including heterocycle formation and a final amidation. No peer-reviewed procedure exists in reality. Structure-activity discussions focus on core ring planarity and polar substituents affecting receptor binding.

See also: eotaxin, CCL11; eosinophil chemokines. This article describes a fictional compound; for real eotaxins see the chemokine CCL11.