Entzündungsabbau

Entzündungsabbau refers to the complex biological process by which inflammation, a crucial defense mechanism, is resolved and terminated. While inflammation is a necessary response to injury or infection, characterized by redness, swelling, heat, and pain, prolonged or excessive inflammation can lead to tissue damage and chronic diseases. The inflammatory response involves the recruitment of immune cells to the affected site, the release of various mediators like cytokines and chemokines, and increased vascular permeability.

Once the initial threat is neutralized, a coordinated series of events is triggered to dampen the inflammatory cascade and initiate tissue repair. This involves the clearance of dead cells and debris by specialized phagocytic cells, such as macrophages, which switch their phenotype to an anti-inflammatory and pro-resolving one. Specialized lipid mediators, known as resolvins, protectins, and maresins, are actively produced and play a critical role in actively promoting the resolution phase. These molecules actively switch off inflammatory signaling pathways and facilitate the return of tissues to their normal state. The efficacy of Entzündungsabbau is vital for maintaining tissue homeostasis and preventing the development of chronic inflammatory conditions. Disruptions in this resolution process are implicated in various diseases, including arthritis, cardiovascular disease, and neurodegenerative disorders.