EAF1s

EAF1s refers to a family of proteins known as ELL-associated factors 1 and its homologs across species. In humans, EAF1 encodes a nuclear protein that interacts with the RNA polymerase II elongation factor ELL and with other partners to form transcription elongation complexes. These complexes modulate transcriptional elongation by RNA Pol II, helping to release stalled polymerase and promote productive elongation of specific genes.

EAF1s function as part of the transcription elongation machinery by forming complexes with ELL and other factors such as EAF2. The exact composition of these complexes can vary by cell type and condition. Through these interactions, EAF1s influence gene expression programs, including developmental and hematopoietic genes in some contexts.

EAF1 family proteins are conserved in vertebrates and some invertebrates. They typically contain regions mediating protein–protein interactions, enabling scaffold roles within transcriptional coactivator complexes.

EAF1 expression is detected in multiple tissues; expression can be regulated during development and differentiation.

Altered expression or function of EAF1 family members has been reported in various cancers and hematopoietic disorders; the causal links remain under study.