E484K

E484K is a specific mutation found in the spike protein of certain SARS-CoV-2 variants. The "E" refers to the amino acid glutamic acid at position 484, which is replaced by "K," representing lysine. This substitution is considered significant because it can affect the virus's ability to evade the immune system and potentially increase its transmissibility or reduce the effectiveness of certain antibody treatments. The E484K mutation has been observed in several notable variants, including the Beta (B.1.351), Gamma (P.1), and some Omicron subvariants. Its presence is closely monitored by public health organizations and researchers worldwide. The precise impact of E484K can vary depending on the specific variant and the combination of other mutations it carries. Understanding the characteristics of this mutation is crucial for ongoing efforts to track viral evolution and develop effective countermeasures.