Doxifluridines
Doxifluridine, also known as 5'-deoxy-5-fluorouridine, is a nucleoside analog that serves as a prodrug of the chemotherapeutic agent 5-fluorouracil (5-FU). It is administered orally to deliver 5-FU systemically, with the aim of achieving tumor-targeted exposure.
Activation occurs primarily through thymidine phosphorylase, an enzyme commonly upregulated in solid tumors, which converts doxifluridine
Pharmacology and administration: After oral dosing, doxifluridine is absorbed and metabolized to 5-FU; its pharmacokinetics are
Clinical status: Doxifluridine has been evaluated in colorectal and gastric cancer, among other indications, as monotherapy