Dolobid

Dolobid is a brand name historically used for the nonsteroidal anti-inflammatory drug diflunisal. Diflunisal is an NSAID indicated for relief of mild to moderate pain and for inflammation associated with conditions such as osteoarthritis and rheumatoid arthritis. It may also be used for short-term treatment of acute musculoskeletal pain. Diflunisal is taken orally as tablets and, like other NSAIDs, works by reducing the production of prostaglandins through non-selective inhibition of cyclooxygenase enzymes, producing analgesic, anti-inflammatory, and antipyretic effects.

Common adverse effects reflect the general NSAID profile and can include gastrointestinal upset (nausea, dyspepsia, and abdominal pain), and, with longer use, risk of ulcers or GI bleeding. Other potential effects include dizziness, headaches, rash, and fluid retention. Diflunisal can impair kidney function and may raise blood pressure; these risks are heightened in older individuals or those with preexisting kidney, liver, or heart disease. As with other NSAIDs, it should be used with caution in patients with a history of GI disease, peptic ulcers, or moderate to severe renal impairment.

Contraindications include known hypersensitivity to diflunisal or other NSAIDs, active GI bleeding or perforation, and severe renal or hepatic impairment. Caution is advised during pregnancy and lactation, and it is generally avoided in individuals with significant comorbidities unless benefits outweigh risks.

Drug interactions may occur with anticoagulants, other NSAIDs, corticosteroids, antihypertensives, and diuretics, potentially increasing GI risk or affecting drug efficacy. Availability and usage of the Dolobid brand vary by country. Always follow current labeling and a clinician’s guidance.