Dissolutiontestejä
Dissolution testing is a critical process in pharmaceutical science used to measure the rate and extent to which an active pharmaceutical ingredient (API) dissolves from a solid dosage form, such as a tablet or capsule, into a specified liquid medium. This process is essential for understanding and ensuring the bioavailability of a drug, which is the portion of the administered dose that reaches the systemic circulation and is available to exert its therapeutic effect.
The fundamental principle behind dissolution testing is to mimic the physiological conditions of the gastrointestinal tract.
The data generated from dissolution tests provides valuable information for several purposes. It is used during