Deltaglobin
Deltaglobin is the delta globin polypeptide, one of the globin chains that form adult hemoglobin. It is encoded by the HBD gene on chromosome 11 and is a component of hemoglobin A2 (HbA2), which in healthy adults typically makes up about 2–3% of total hemoglobin. HbA2 consists of two alpha chains and two delta chains (α2δ2).
Delta-globin belongs to the beta-like globin gene family and is expressed in erythroid cells. Its production
Regulation of deltaglobin expression is part of the broader developmental switch that controls globin gene expression.
Clinical significance of delta-globin relates mainly to genetic disorders affecting the HBD gene. Delta-thalassemia, caused by
In summary, deltaglobin is the delta chain of HbA2, encoded by HBD, contributing to a small but