DRRF1

DRRF1, also known as DDB2-binding protein or DNA damage-regulated protein 1, is a protein encoded by the DRRF1 gene. This gene is conserved across various species, suggesting a fundamental biological role. DRRF1 has been implicated in cellular responses to DNA damage. Specifically, it appears to interact with DDB2, a protein known to play a crucial part in DNA repair pathways, particularly nucleotide excision repair. The interaction between DRRF1 and DDB2 suggests that DRRF1 might be involved in recognizing and initiating the repair of damaged DNA. Studies indicate that DRRF1 can be upregulated in response to genotoxic stress, further supporting its involvement in DNA damage response mechanisms. Its precise molecular function and the full scope of its interactions within cellular signaling pathways are still areas of active research. Understanding DRRF1's role could provide insights into cellular resilience and the development of novel therapeutic strategies for conditions involving DNA integrity.