DOTAconjugated
DOTAconjugated refers to molecules where 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) is covalently attached to another chemical entity. DOTA is a macrocyclic chelator widely used in radiopharmaceuticals and imaging agents. Its primary function is to bind strongly and stably to various metal ions, particularly lanthanides like Gadolinium (Gd) and radioactive isotopes such as Lutetium-177 (Lu-177) and Gallium-68 (Ga-68).
The conjugation of DOTA to a targeting moiety, such as a peptide, antibody, or small molecule, creates
The stability of the DOTA-metal complex is crucial to prevent the release of the potentially toxic metal