DNaseseq

DNaseseq is an open-source software platform for processing, analyzing, and visualizing DNA sequencing data. It provides an end-to-end workflow from raw reads to annotated variants within a modular framework. The project is platform-agnostic and extensible via plugins, supporting FASTQ, FASTA, SAM/BAM, CRAM, and VCF formats, with pipelines for short- and long-read technologies. A built-in workflow engine enables reproducible analyses, and it offers both a graphical user interface and a command-line interface.

DNaseseq includes quality-control modules such as per-base metrics, adapter trimming, duplication assessment, and contamination checks. In variant discovery, it offers SNP and indel calling, joint genotyping options, and genotype filtering. Annotation features connect to gene models and public databases, and visualization tools include genome browsers and coverage plots. The platform targets academic research, education, and exploratory analysis, emphasizing reproducible pipelines and versioned configurations.

DNaseseq originated in the mid-2010s as a collaborative project in computational genomics and has since evolved through international contributions and regular releases, focusing on performance, interoperability, and user experience.

Related topics include genome sequencing, bioinformatics, read alignment, variant calling, and data visualization.