DNAJC6

DNAJC6, also known as Auxilin, is a protein-coding gene. The protein it encodes is a member of the heat shock protein 40 (HSP40) family, also referred to as J-domain proteins. These proteins are characterized by the presence of a conserved J-domain, which is essential for their interaction with heat shock protein 70 (HSP70) chaperones. DNAJC6 plays a crucial role in the process of clathrin-mediated endocytosis, a fundamental cellular mechanism for internalizing molecules and regulating cell surface receptors. Specifically, the DNAJC6 protein assists in the uncoating of clathrin-coated vesicles after they have been internalized into the cell. This uncoating step is vital for the proper trafficking and function of internalized components. Mutations in the DNAJC6 gene have been linked to certain neurological disorders, including Parkinson's disease and intellectual disability, highlighting its importance in neuronal function and development. Research into the precise mechanisms and functions of DNAJC6 is ongoing, with a focus on its interactions with other proteins and its involvement in various cellular pathways.