CohesinKomplex
The Cohesin Complex, known in German-language literature as the CohesinKomplex, is a highly conserved multi-subunit protein complex essential for sister chromatid cohesion, chromatin organization, and DNA repair. It forms a ring-like structure that can encircle two sister chromatids, thereby holding them together from DNA replication in S phase until their separation in mitosis. Beyond cohesion, cohesin also contributes to higher-order chromosome architecture and regulation of gene expression.
The core subunits are two structural maintenance of chromosome (SMC) proteins, SMC1 and SMC3, which form a
Loading and establishment of cohesion occur mainly during the cell cycle's S phase. The ring is loaded
Functions extend beyond cohesion to the organization of chromatin loops and topologically associating domains, guidance of
Dysfunction of cohesin components or regulators is linked to human disorders, including Cornelia de Lange syndrome,