Celleaggregationstests

Celleaggregationstests, also known as cell aggregation tests, are laboratory procedures used to assess the ability of blood cells to clump together. These tests are crucial in diagnosing and monitoring various hematological disorders, particularly those related to the immune system. The most common type of cell aggregation test is the platelet aggregation test, which evaluates the aggregation of platelets in response to various stimuli.

Platelet aggregation tests are typically performed using a platelet aggregometer, a device that measures the changes in light transmission as platelets aggregate and form a clot. The test involves mixing a sample of the patient's blood with a platelet aggregating agent, such as adenosine diphosphate (ADP), collagen, or epinephrine. The rate and extent of platelet aggregation are then recorded and analyzed.

Cell aggregation tests can help identify conditions such as von Willebrand disease, Glanzmann's thrombasthenia, and other platelet function disorders. They are also used to monitor the effectiveness of antiplatelet therapies in patients with conditions like thrombosis and atherosclerosis. Additionally, these tests can be used to evaluate the efficacy of new drugs in clinical trials.

The results of cell aggregation tests are usually expressed as a percentage of maximum aggregation or as the time taken to reach a specific level of aggregation. These results are interpreted by a hematologist or a clinical laboratory scientist, who can provide a diagnosis or assess the response to treatment based on the patient's clinical history and other laboratory findings.