Cdk1Ciklin
CDK1-Cyclin, often referred to as the CDK1–Cyclin complex, is a central driver of the eukaryotic cell cycle, with particular importance for the transition from G2 phase into mitosis. In many organisms, CDK1 is the essential catalytic subunit, while cyclins provide regulatory input that dictates when the kinase is active. The classic mitotic partner is Cyclin B, but CDK1 can associate with other cyclins in different cellular contexts, contributing to various cell-cycle events.
Activation and regulation of the complex rely on phosphorylation states. A CDK-activating kinase (CAK) phosphorylates CDK1
CDK1–Cyclin targets a broad set of substrates to drive mitotic events, including nuclear envelope breakdown, chromosome