Carbapenemcontaining
Carbapenem-containing refers to antibiotics that include a carbapenem as the active component or to formulations that pair a carbapenem with another agent. Carbapenems are a subclass of beta-lactam antibiotics with broad-spectrum activity against many Gram-positive and Gram-negative bacteria, including several multidrug-resistant strains. They are commonly reserved for serious, hospital-acquired infections and for complicated cases where resistance limits other options.
Mechanism-wise, carbapenems inhibit bacterial cell wall synthesis by binding to penicillin-binding proteins. They tend to be
Representative single-agent carbapenems include imipenem, meropenem, ertapenem, and doripenem. In addition, several combination products pair a
Administration is typically intravenous and confined to hospital settings or controlled clinical environments. Pharmacokinetics are influenced
See also: beta-lactam antibiotics, carbapenemases, antibiotic resistance, antimicrobial stewardship.