Ca2calmoduline
Ca2+-calmodulin (Ca2+-CaM) refers to the calcium-bound form of calmodulin, a ubiquitously expressed intracellular calcium-binding messenger protein found in all eukaryotes. It functions as a versatile signal transducer that translates changes in intracellular Ca2+ concentration into modulation of a broad range of target proteins and enzymes.
Calmodulin is a small acidic protein of about 17 kilodaltons, consisting of 148 amino acids arranged in
When bound to Ca2+, calmodulin modulates a variety of enzymes and channels, such as myosin light-chain kinase
Calmodulin is encoded by three highly conserved genes in humans (CALM1, CALM2, CALM3); their encoded proteins