CYP2R1encoded

CYP2R1encoded refers to the protein product of the CYP2R1 gene, also known as Vitamin D 25-hydroxylase. This enzyme plays a crucial role in the initial step of vitamin D metabolism. The CYP2R1 gene is a member of the cytochrome P450 superfamily, which are known for their involvement in a wide range of metabolic processes, including the synthesis and breakdown of various compounds.

Specifically, CYP2R1 is primarily responsible for hydroxylating vitamin D at the 25-position, converting it into 25-hydroxyvitamin D (also known as calcidiol). This 25-hydroxylated form is the major circulating metabolite of vitamin D and is considered the best indicator of vitamin D status in the body. Calcidiol is then further metabolized in the kidneys to the active form, 1,25-dihydroxyvitamin D (calcitriol), which is essential for calcium absorption and bone health.

Variations in the CYP2R1 gene can affect the enzyme's activity, potentially influencing an individual's ability to metabolize vitamin D and maintain adequate levels of 25-hydroxyvitamin D. This can have implications for bone health and calcium homeostasis. Research into CYP2R1 continues to explore its precise functions, its role in various physiological and pathological conditions, and the potential impact of genetic polymorphisms on vitamin D levels and related health outcomes.