CTLA4hämmarna
CTLA-4 inhibitors, also known as CTLA4 blockers, are a class of immunomodulatory drugs that work by blocking the activity of the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4). CTLA-4 is a protein expressed on the surface of T cells, a type of white blood cell that plays a crucial role in the immune system's response to foreign invaders and abnormal cells.
Under normal circumstances, CTLA-4 acts as an immune checkpoint, essentially a brake on the immune system. It
CTLA-4 inhibitors, such as ipilimumab, are designed to release this "brake." By blocking the interaction between
These inhibitors have found significant application in the field of oncology, particularly in the treatment of