CSTF2T
CSTF2T is a protein encoded by the CSTF2T gene in humans. It is a paralog of the core cleavage stimulation factor CSTF2 and is thought to be part of the cleavage stimulation factor (CSTF) complex involved in 3' end processing and polyadenylation of pre-mRNA.
Expression is primarily in the testis and germ cells, suggesting a role in spermatogenesis; in other tissues,
Biochemical role: participates in recognition of downstream elements and promotes cleavage and polyadenylation by interacting with
Evolution: conserved paralog among vertebrates; arises via gene duplication; may show divergence in expression pattern.
Clinical relevance: limited direct associations; studied mainly for understanding testis-specific RNA processing; potential involvement in male
Research continues to clarify its precise interactions, regulatory mechanisms, and potential roles in tissue-specific polyadenylation.