CRHtest

CRHtest, also known as the Corticotropin-Releasing Hormone test, is a diagnostic procedure used to assess the functionality of the hypothalamic-pituitary-adrenal (HPA) axis. This test evaluates the body's response to corticotropin-releasing hormone (CRH), which stimulates the secretion of adrenocorticotropic hormone (ACTH) from the pituitary gland and subsequently increases cortisol production from the adrenal glands.

The CRH test is commonly employed to differentiate between various causes of adrenal and pituitary disorders, such as Cushing's syndrome and secondary adrenal insufficiency. It can help determine whether the hypothalamus and pituitary are functioning properly or if there is a dysfunction that affects cortisol regulation.

During the procedure, synthetic CRH is administered intravenously, and blood samples are collected at intervals to measure levels of ACTH and cortisol. An appropriate increase in these hormones indicates a normal response of the HPA axis, whereas blunted or absent responses suggest underlying pathology.

The CRH test has largely replaced the overnight dexamethasone suppression test and other assessments in certain clinical contexts. It is generally well-tolerated with minimal side effects, although some patients may experience transient nausea, headache, or flushing.

While highly informative, the CRH test is typically performed in specialized centers and interpreted in conjunction with other clinical findings and laboratory results. Its use is particularly valuable in complex cases where the diagnosis of adrenal or pituitary abnormalities remains uncertain.