CMPNeu5Acn
CMPNeu5Acn, more commonly called CMP-Neu5Ac, is the activated cytidine monophosphate form of N-acetylneuraminic acid. It serves as the donor substrate for sialyltransferases, enzymes that attach sialic acid to glycoconjugates on glycoproteins and glycolipids in the secretory pathway.
Biosynthesis begins with the production of N-acetylneuraminic acid (Neu5Ac) in the cytosol via the sialic acid
Functionally, sialylation mediated by CMP-Neu5Ac influences many aspects of cell biology, including cell–cell and cell–matrix interactions,
Clinical and research notes: Alterations in CMP-Neu5Ac metabolism or its transport can perturb glycan structures and