CKMBfraktio

CKMBfraktio refers to the fractional amount of creatine kinase-myocardial band (CK-MB) in a patient's blood. Creatine kinase is an enzyme found in various tissues, including the heart muscle. CK-MB is a specific isoenzyme of creatine kinase that is predominantly found in the heart. When heart muscle is damaged, such as during a heart attack (myocardial infarction), CK-MB is released into the bloodstream. Measuring the level of CK-MB can help diagnose and assess the extent of cardiac damage.

The "fraktio" aspect, meaning fractional or percentage, typically relates to the ratio of CK-MB to the total creatine kinase (CK) level. This ratio, often referred to as the CK-MB index, can be more specific for cardiac injury than simply looking at the total CK level, as other conditions can elevate total CK without indicating heart damage. A higher CK-MBfraktio or CK-MB index is more suggestive of myocardial injury.

Historically, CK-MB levels and the CK-MB index were crucial biomarkers for diagnosing acute myocardial infarction. However, with the advent of more sensitive and specific cardiac troponin assays, the use of CK-MB for routine diagnosis of heart attacks has significantly decreased. Troponins are now the preferred biomarkers due to their higher specificity for cardiac muscle and longer detection window. Nonetheless, CK-MB may still be utilized in certain clinical scenarios, particularly in the early stages following chest pain onset, or in conjunction with other diagnostic tools.