CD95naCD95L

CD95naCD95L is a fusion protein that results from the genetic rearrangement between the CD95 (also known as Fas) and CD95L (Fas ligand) genes. This rearrangement typically occurs in T-cell acute lymphoblastic leukemia (T-ALL) and is associated with a poor prognosis. The CD95naCD95L fusion protein is characterized by the loss of the CD95 extracellular domain and the retention of the CD95L transmembrane and cytoplasmic domains. This fusion protein is constitutively active and can induce apoptosis in CD95-expressing cells, leading to the destruction of normal T cells and contributing to the pathogenesis of T-ALL. The presence of CD95naCD95L is a significant prognostic marker in T-ALL, with patients expressing this fusion protein having a worse overall survival compared to those without it. The exact mechanism by which CD95naCD95L contributes to T-ALL pathogenesis is not fully understood, but it is believed to play a role in the dysregulation of apoptosis and the accumulation of leukemic cells.