CD89FcRI

CD89FcRI refers to a specific type of engineered antibody fragment. It combines features of CD89, also known as the Fc receptor for IgA (FcαRI), with an Fc fragment of an antibody, likely IgG. The Fc fragment of IgG is known for its ability to interact with Fc receptors on immune cells, such as FcγRs. By fusing a portion of CD89, which binds IgA, to an Fc fragment, researchers aim to create a molecule with novel binding properties. This construct could potentially bridge IgA-mediated immune responses with the effector functions typically associated with IgG Fc receptor engagement. Such engineered proteins are often designed for therapeutic or diagnostic purposes, for instance, to enhance the targeting of immune cells to IgA-coated pathogens or tumor cells, or to modulate immune responses. The specific applications and biological activity of CD89FcRI would depend on the precise design and context of its use.