CD163related

CD163, also known as cluster of differentiation 163, is a receptor protein that plays a significant role in the immune system, particularly in the recognition and clearance of foreign substances and pathogens.

CD163 is primarily expressed on the surface of macrophages and monocytes, which are types of white blood cells involved in the detection and elimination of infection and inflammation. This receptor protein recognizes and binds to hemoglobin and anti-inflammatory cytokines, such as interleukin-10 and transforming growth factor-beta, indicating that CD163 may be involved in the regulation of inflammation.

The CD163 gene, located on chromosome 12, codes for a transmembrane receptor that has a structure similar to other receptors known as scavenger receptors. CD163 is involved in the clearance of immunoglobulin G immune complexes, which can contribute to tissue damage in autoimmune diseases. Aberrant CD163 expression has been linked to various conditions, including cancer, autoimmune disease, and chronic inflammation.

Studies have shown that CD163 expression may be affected by different factors, including the presence of toxins and oxidative stress. CD163 also appears to be regulated by several transcription factors, such as nuclear factor kappa B and specificity protein 1, which can influence its expression levels in response to environmental stimuli.

Overall, CD163 is a key component of the immune system, involved in the detection and clearance of foreign substances and the modulation of inflammation. Further research is needed to fully elucidate the role of CD163 in human health and disease.