CCR3Rezeptor
CCR3 receptor, short for C-C chemokine receptor type 3, is a chemokine receptor belonging to the class A G protein-coupled receptors. It is expressed mainly on eosinophils, basophils, mast cells, and certain T helper 2 cells, with additional expression in some dendritic cells and airway epithelial cells under inflammatory conditions.
Ligands provide the primary functional input for CCR3. The main ligands are the eotaxins: CCL11 (eotaxin-1),
Physiological role involves mediating the recruitment of eosinophils and other CCR3-expressing cells to sites of inflammation.
Clinical significance centers on its involvement in eosinophilic airway inflammation in allergic diseases. CCR3 is considered
Genetics and expression note that the CCR3 gene is located on chromosome 3 in humans. It is