CARMA3

CARMA3, also known as CARD-like molecule associated protein 3, is a protein encoded by the CARMA3 gene in humans. It is a member of the CARD-MAGUK protein family, which are involved in various cellular processes including cell adhesion, cell proliferation, and immune signaling. CARMA3 specifically plays a role in the development and function of the immune system. It has been implicated in regulating T cell activation and apoptosis, processes crucial for adaptive immunity. Furthermore, CARMA3 has been observed to interact with other signaling molecules within the cell, contributing to complex intracellular pathways. Research into CARMA3 is ongoing to fully elucidate its diverse functions and its potential involvement in diseases. Its expression patterns are observed in various tissues, with particular significance in immune cells. The protein's modular structure, featuring a CARD domain and a MAGUK domain, allows it to bind to different partners and mediate distinct cellular responses. Understanding the precise mechanisms by which CARMA3 operates is an active area of investigation within molecular biology and immunology.