CALB2

CALB2, also known as Calbindin 2, is a calcium-binding protein. It belongs to the calbindin family of proteins, which are involved in various cellular processes that are regulated by calcium ions. CALB2 is primarily expressed in the central nervous system, particularly in neurons and glial cells, as well as in certain peripheral tissues like the kidneys and intestines. Its precise function is still an area of active research, but it is believed to play roles in calcium buffering, signal transduction, and the regulation of calcium homeostasis within cells.

Studies have suggested that CALB2 may be involved in protecting neurons from excitotoxicity and oxidative stress, which are implicated in neurodegenerative diseases. Alterations in CALB2 expression or function have been observed in various neurological conditions, including epilepsy and Alzheimer's disease, hinting at its potential involvement in disease pathogenesis. Furthermore, its presence in the kidneys suggests a role in calcium reabsorption and regulation in this organ. Research into CALB2 continues to explore its diverse physiological functions and potential therapeutic applications.