C1esterasehämmare

C1esterasehämmare refers to a class of drugs that inhibit the activity of C1 esterase, an enzyme involved in the complement system and the coagulation cascade. These inhibitors are primarily used to treat hereditary angioedema (HAE), a rare genetic disorder characterized by recurrent episodes of swelling in various parts of the body. C1 esterase plays a crucial role in regulating these inflammatory processes. In individuals with HAE, a deficiency or dysfunction of C1 esterase leads to uncontrolled activation of the complement system and the release of bradykinin, a potent vasodilator that causes angioedema. C1esterasehämmare work by blocking the activity of C1 esterase, thereby reducing the production of bradykinin and preventing or treating angioedema attacks. These medications can be administered intravenously or subcutaneously and are available in both plasma-derived and recombinant forms. They represent a significant advancement in the management of HAE, offering relief from debilitating symptoms and improving the quality of life for affected individuals.