BMMNCs

BMMNCs stands for Bone Marrow Mononuclear Cells. This is a term used to describe a specific population of cells found in the bone marrow. These cells are characterized by having a single nucleus and are separated from other bone marrow components during a laboratory procedure called density gradient centrifugation. The fraction that remains after this separation, which floats at a specific density layer, is enriched for BMMNCs.

The primary components of BMMNCs are hematopoietic stem cells and progenitor cells. Hematopoietic stem cells are multipotent cells that can differentiate into all types of blood cells, including red blood cells, white blood cells, and platelets. Progenitor cells are more committed cells that are on their way to becoming specific blood cell lineages. The BMMNC fraction also contains other cells such as lymphocytes, monocytes, and early precursors of myeloid and erythroid lineages.

Due to their rich content of stem and progenitor cells, BMMNCs have significant applications in regenerative medicine and transplantation. They are commonly used in bone marrow transplantation to reconstitute the blood and immune system of patients with certain cancers or blood disorders. Research is also ongoing into using BMMNCs for tissue repair and regeneration in various organs. The isolation and manipulation of BMMNCs are crucial techniques in both clinical practice and biomedical research.