BGT1

BGT1, also known as SLC21A3 or MRP3, is a protein that functions as an organic anion transporter. It belongs to the ATP-binding cassette (ABC) transporter superfamily. BGT1 plays a role in the transport of various organic anions across cell membranes. These anions include bile acids, prostaglandins, and certain drugs. The transporter is expressed in several tissues, notably in the liver and kidneys, where it contributes to the excretion of these substances from the body. In the liver, it can efflux conjugated bile acids from hepatocytes into the bloodstream. In the kidneys, it is found in the basolateral membrane of proximal tubule cells and is involved in the reabsorption of organic anions from the glomerular filtrate back into the blood. Dysfunction of BGT1 has been implicated in certain disease states, particularly those involving cholestasis or impaired drug metabolism. Its activity is dependent on cellular energy in the form of ATP. Research into BGT1 continues to explore its precise physiological roles and potential as a therapeutic target for various conditions.