Atg17Atg29Atg31
Atg17Atg29Atg31 refers to a core protein complex in the Saccharomyces cerevisiae autophagy pathway, formed by the autophagy-related proteins Atg17, Atg29, and Atg31. These components function within the Atg1 kinase complex, which is mobilized under nutrient limitation to initiate autophagosome formation. Atg17 serves as a coiled-coil scaffold that dimerizes to provide a structural platform at the pre-autophagosomal structure (PAS). Atg29 and Atg31 form a heterodimer that associates with Atg17, producing a scaffold essential for organizing the PAS and supporting autophagosome biogenesis.
The complex localizes to the PAS and acts to recruit and stabilize other autophagy factors, including Atg1
Regulation of the complex involves nutrient status and post-translational modifications that influence protein–protein interactions within the