Amilorida
Amilorida (amiloride) is a potassium-sparing diuretic used to treat hypertension, edema associated with congestive heart failure, and certain disorders that cause abnormal sodium retention. It is a synthetic pyrazinoylguanidine that acts on the distal nephron of the kidney.
Amilorida’s primary mechanism is direct inhibition of epithelial sodium channels (ENaC) in the principal cells of
Clinically, amilorida is commonly prescribed alone or in combination with thiazide diuretics to limit thiazide-induced hypokalemia.
Adverse effects include hyperkalemia, particularly in patients with renal impairment or those taking ACE inhibitors, ARBs,