Amidegroep
The amide group is a functional group consisting of a carbonyl group (C=O) connected to a nitrogen atom (NH2) through a single bond. It is a common structural motif found in many organic compounds, particularly in proteins and peptides, where it serves as the primary linkage between amino acids. The amide group is characterized by its planar structure, with the nitrogen atom typically sp2 hybridized, and the carbonyl carbon atom also sp2 hybridized. This planar structure allows for the formation of hydrogen bonds, which are crucial for the secondary and tertiary structures of proteins.
Amides can be classified based on the substituents attached to the nitrogen atom. Primary amides have one
Amides are often synthesized through the reaction of a carboxylic acid with an amine in the presence