ATRPlike

ATRPlike refers to proteins that share structural and functional similarities with Aurora-related kinases (ARKs) and members of the Aurora kinase family. While the Aurora kinases are a well-characterized group of serine/threonine kinases crucial for cell division, ATRPlike proteins represent a broader category of related kinases. These proteins often play roles in cell cycle regulation, spindle assembly, and chromosome segregation, echoing the functions of classical Aurora kinases. However, ATRPlike proteins may possess distinct regulatory mechanisms, substrate specificities, or cellular localization, leading to specialized roles within the cell. The study of ATRPlike proteins helps to expand our understanding of the broader kinase superfamily involved in mitotic progression and other cellular processes. Identifying and characterizing ATRPlike proteins is an ongoing area of research in cell biology and cancer biology, as dysregulation of these kinases can contribute to genomic instability and tumorigenesis. Their involvement in mitosis makes them potential targets for cancer therapeutics.