AMLM3

AMLM3 is a gene located on chromosome 19q13.2, which encodes a protein involved in the regulation of cell proliferation and differentiation. The gene is part of the AML1-MLL gene fusion family, which is commonly associated with acute myeloid leukemia (AML). The AML1-MLL gene fusions result from chromosomal translocations, leading to the fusion of the AML1 gene with various partner genes, including MLL. The AMLM3 gene is one of the partner genes that can fuse with AML1, forming the AML1-MLL3 fusion protein. This fusion protein is known to disrupt the normal function of the AML1 protein, leading to the dysregulation of cell proliferation and differentiation, which is a hallmark of AML. The AML1-MLL3 fusion protein has been shown to have oncogenic properties, contributing to the development and progression of AML. The identification of AMLM3 as a partner gene in the AML1-MLL fusion family has provided valuable insights into the molecular mechanisms underlying AML and has the potential to inform the development of targeted therapies for this disease.