ALSn

ALSn, also known as Actin-like protein 4, is a protein that in humans is encoded by the ACTN4 gene. This gene is located on chromosome 12q24.31. ALSn is a member of the actin superfamily, which includes actin and other proteins involved in cell structure and motility. The protein is expressed in various tissues, including skeletal muscle, heart, and brain.

The ACTN4 gene spans approximately 10.5 kilobases and contains 12 exons. It is highly conserved across species, indicating its importance in fundamental biological processes. The protein encoded by this gene is a member of the actin family, characterized by a highly conserved core domain that is essential for its function.

ALSn plays a crucial role in muscle contraction and relaxation. In skeletal muscle, it forms part of the thin filament, where it interacts with myosin to generate force. In cardiac muscle, ALSn is involved in the regulation of heart contraction and relaxation. Mutations in the ACTN4 gene have been associated with several genetic disorders, including hypertrophic cardiomyopathy, a condition characterized by the enlargement of the heart muscle.

The protein's structure and function have been extensively studied, with numerous research papers published on the topic. ALSn is also a target for various therapeutic interventions, particularly in the treatment of cardiac diseases. Ongoing research aims to elucidate the molecular mechanisms underlying ALSn's function and to develop novel therapies based on its modulation.