ALKBH1

ALKBH1, also known as AlkB homolog 1, is a human gene that encodes a DNA repair enzyme. This enzyme belongs to the AlkB family of dioxygenases, which are known for their ability to repair oxidative DNA damage. Specifically, ALKBH1 is involved in the demethylation of N1-methyladenine and N3-methylcytosine lesions in DNA. These types of damage can arise from exposure to alkylating agents and can interfere with DNA replication and transcription if not repaired.

The protein encoded by ALKBH1 plays a crucial role in maintaining genomic stability. Its activity is essential for removing specific alkylation adducts that can otherwise lead to mutations. Studies suggest that ALKBH1 functions in a base excision repair pathway, working in conjunction with other DNA repair proteins. Research has indicated that ALKBH1 may also have roles beyond DNA repair, with some investigations exploring its potential involvement in cellular processes like gene expression regulation and cell cycle control. The exact mechanisms and full range of functions of ALKBH1 are still areas of active scientific inquiry.