AGRN

AGRN, also known as alpha-spectrin, is a protein encoded by the AGRN gene. This gene is a member of the spectrin gene family, which are cytoskeletal proteins involved in maintaining cell shape and structure. Alpha-spectrin plays a crucial role in the organization of the cytoskeleton in various cell types, including red blood cells and neurons. In red blood cells, it forms a network beneath the plasma membrane, providing mechanical stability and flexibility, which is essential for their passage through narrow capillaries. In neurons, AGRN is found in the postsynaptic density, a complex structure at synapses that is important for neuronal signaling. It interacts with other proteins to form a scaffolding that stabilizes receptors and signaling molecules. Mutations in the AGRN gene have been associated with certain neurological disorders, suggesting its importance in proper brain development and function. Research into AGRN continues to shed light on its diverse roles in cellular mechanics and signaling pathways.