ADAT2ADAT3s

ADAT2ADAT3s, also known as ADAT2 and ADAT3, are enzymes belonging to the family of alpha-amino acid N-acyltransferases. These enzymes play a crucial role in cellular metabolism by facilitating the transfer of an acyl group from a donor molecule, typically an N-acyl-amino acid, to an acceptor molecule, often a free amino acid. This transamidation reaction is important for various biological processes, including the metabolism of xenobiotics and the regulation of amino acid homeostasis.

ADAT2 and ADAT3 are known to form a heteromeric complex, which is thought to be essential for their catalytic activity. The precise biological functions of ADAT2ADAT3s are still under investigation, but they have been implicated in pathways related to protein synthesis, amino acid catabolism, and detoxification. Research suggests that these enzymes may also be involved in the regulation of gene expression and cell signaling.

Mutations or dysregulation of ADAT2ADAT3 activity have been associated with certain metabolic disorders and diseases, although these links are not fully established. The study of ADAT2ADAT3s contributes to our understanding of fundamental metabolic pathways and could potentially lead to the development of new therapeutic strategies for related conditions. Further research is ongoing to elucidate the complete spectrum of their physiological roles and the consequences of their dysfunction.