ADAT2ADAT3

ADAT2ADAT3 is a gene fusion that occurs when the ADAT2 gene and the ADAT3 gene are combined. This fusion can result from chromosomal rearrangements, such as translocations or inversions, which bring the two genes together in the same reading frame. The ADAT2ADAT3 fusion gene encodes a protein that combines the functions of both ADAT2 and ADAT3.

ADAT2 (Adenosine Deaminase 2) is an enzyme that catalyzes the conversion of adenosine to inosine. ADAT3 (Adenosine Deaminase 3) is another enzyme that also converts adenosine to inosine. The fusion of these two genes can lead to altered enzymatic activity, potentially affecting the cellular metabolism of adenosine and inosine.

The ADAT2ADAT3 fusion has been observed in various types of cancers, including breast cancer, lung cancer, and leukemia. The exact role of this fusion in cancer development and progression is not fully understood, but it is believed to contribute to the malignant phenotype by altering cellular signaling pathways and metabolic processes.

Research on the ADAT2ADAT3 fusion is ongoing, with studies focusing on its potential as a therapeutic target. Understanding the molecular mechanisms underlying this fusion and its impact on cancer cells may lead to the development of new treatments for cancer patients. Further investigation is needed to elucidate the full scope of ADAT2ADAT3's role in disease and to explore its potential as a therapeutic target.