52988

52988 is a part of a cytokine receptor family consisting of a pair of cytokine receptor chains: IL-12R beta 1 and IL-12R beta 2. These receptors are essential for the cellular response to the cytokine interleukin-12 (IL-12), which is involved in regulating the immune response, particularly in T cell function and the activation of natural killer cells.

The 52988 receptor complex is crucial for the recognition and signaling of IL-12, a heterodimeric cytokine composed of two subunits: IL-12 p35 and IL-12 p40. Upon binding of IL-12 to the 52988 receptor, a signaling cascade is initiated that ultimately leads to the activation of downstream pathways involved in the immune response, including the activation of T cells and the production of other cytokines.

IL-12 signaling through the 52988 receptor is implicated in various biological processes, including the regulation of innate and adaptive immunity, inflammation, and the balance between regulatory and effector T cells. The 52988 receptor is also involved in the development of autoimmune diseases, where dysregulation of the IL-12/IL-12R pathway has been implicated in the pathogenesis of conditions such as multiple sclerosis and lupus.

The 52988 receptor has been studied extensively in the context of cytokine biology and its role in the regulation of immunity. Further research is needed to fully elucidate the mechanisms underlying IL-12 signaling and its significance in various biological processes.