3deoxyDmanno2octulonic
3-deoxy-D-manno-2-octulosonic acid, often abbreviated as KDO, is a non-ulosonic acid found in the lipopolysaccharide (LPS) of Gram-negative bacteria. It is a nine-carbon sugar acid that plays a crucial role in the structure and function of the bacterial outer membrane. KDO is a characteristic component of the inner core region of LPS, linking the lipid A portion to the more distal O-antigen.
The biosynthesis of KDO is an essential process for the survival of many Gram-negative bacteria, making it
KDO's unique structure, particularly the presence of a carboxylic acid group and the deoxy position, contributes