2Methylimidazole

2-Methylimidazole, or 2-methyl-1H-imidazole, is an organic heterocycle in the imidazole family. It consists of a five-membered aromatic ring containing two nitrogen atoms, with a methyl group attached to the C2 position. Its molecular formula is C4H6N2. Like imidazole itself, 2-methylimidazole can act as a weak base and a potential ligand in coordination chemistry.

In terms of physical properties, 2-methylimidazole is typically described as a colorless solid at room temperature that is soluble in water and many organic solvents. The ring structure provides two nitrogen atoms that can participate in hydrogen bonding and metal coordination, making the compound useful as a building block in various chemical applications.

Uses and applications of 2-methylimidazole center on coordination chemistry and materials synthesis. It is widely employed as a ligand to form metal–organic complexes and is a key precursor in the synthesis of zeolitic imidazolate frameworks (ZIFs), such as ZIF-8, where 2-methylimidazole-derived ligands bridge metal centers to create porous frameworks. Beyond MOFs, the compound serves as a reagent and intermediate in organic synthesis and pharmaceutical research, where the imidazole core is a common motif.

Synthesis and availability are straightforward in the chemical supply market. 2-Methylimidazole can be prepared by methylation of imidazole at the 2-position or through other established synthetic routes from suitable precursors. It is commercially available from chemical vendors and used as a standard reagent in laboratories.

Safety considerations include handling the compound with appropriate precautions, as it can be an irritant. Use in a well-ventilated area with suitable protective equipment to avoid inhalation, ingestion, or skin contact.