25dimethoxy
25-dimethoxy is a descriptor used in organic chemistry and pharmacology to indicate two methoxy groups (–OCH3) attached to a benzene ring at the 2 and 5 positions. It is not a single chemical, but a motif that appears in several families of psychoactive substances, particularly among phenethylamines and amphetamines.
Within the 2,5-dimethoxyphenethylamine family, compounds such as 2,5-dimethoxyamphetamine (2,5-DMA) have been reported in early literature and
Another prominent group is the DOx series, which are 2,5-dimethoxy-4-substituted amphetamines. Examples include DOM (2,5-dimethoxy-4-methylamphetamine), DOI
The descriptor is also used in NBOMe compounds such as 25I-NBOMe, 25C-NBOMe, and related analogues. These are
Because the 2,5-dimethoxy motif appears across multiple compounds with differing pharmacology and risk profiles, legal status