25dimethoxy

25-dimethoxy is a descriptor used in organic chemistry and pharmacology to indicate two methoxy groups (–OCH3) attached to a benzene ring at the 2 and 5 positions. It is not a single chemical, but a motif that appears in several families of psychoactive substances, particularly among phenethylamines and amphetamines.

Within the 2,5-dimethoxyphenethylamine family, compounds such as 2,5-dimethoxyamphetamine (2,5-DMA) have been reported in early literature and later as research chemicals; these compounds are studied mainly in pharmacology and toxicology contexts rather than as approved medicines.

Another prominent group is the DOx series, which are 2,5-dimethoxy-4-substituted amphetamines. Examples include DOM (2,5-dimethoxy-4-methylamphetamine), DOI (2,5-dimethoxy-4-iodoamphetamine), and DOET (2,5-dimethoxy-4-ethylamphetamine). These substances have been described in historical and contemporary sources as psychedelics with varying potency and duration.

The descriptor is also used in NBOMe compounds such as 25I-NBOMe, 25C-NBOMe, and related analogues. These are highly potent serotonergic hallucinogens that have been associated with adverse health effects and have faced regulatory controls in many jurisdictions.

Because the 2,5-dimethoxy motif appears across multiple compounds with differing pharmacology and risk profiles, legal status typically falls under broader drug-control laws rather than a single substance. These compounds can be dangerous, and production, distribution, or possession may be illegal in many countries.