23dihydroindol3one

23dihydroindol3one, also known as oxindole, is an organic compound with the chemical formula C8H7NO. It is a bicyclic molecule consisting of a benzene ring fused to a five-membered nitrogen-containing ring, with a ketone group at the 3-position. Oxindole is a colorless solid at room temperature and is slightly soluble in water.

Oxindole derivatives are found in various natural products and have attracted significant interest in medicinal chemistry due to their diverse biological activities. These activities include anti-inflammatory, anti-cancer, and anti-viral properties. Many pharmaceutical drugs and drug candidates incorporate the oxindole scaffold. For example, sunitinib, a tyrosine kinase inhibitor used to treat certain types of cancer, contains an oxindole core.

The synthesis of oxindole and its derivatives can be achieved through several methods, including cyclization reactions of aniline derivatives. These synthetic routes allow for the modification of the oxindole structure to create novel compounds with tailored properties. The chemical reactivity of oxindole, particularly at the alpha-carbon adjacent to the carbonyl group, allows for further functionalization and the development of complex molecules. Its presence in natural sources and its synthetic versatility make oxindole an important building block in organic chemistry and drug discovery.